The system has 4 monitors arranged in 2x2 box configuration.

Start a PowerPoint show spanning across 4 monitors arranged in 2x2 box layout.

Follow these steps to launch a Multi-Panel Show for the specified requirements:

Open the presentation that should participate in the PowerShow session. Lets call it "Seven Wonders.ppt" for this session.

Select Slide Show tab, clear the Use Presenter View box.

Start Multi-Panel Show by selecting Slide Show | Multi-Panel Show item within Microsoft PowerPoint.